ABSTRACT
In present study, the inhibitory potential of Neolamarckia cadamba phytoconstituents was investigated against SARS-CoV-2 3CL protease (3CL pro) (PDB ID: 6M2N). Molecular docking was analyzed using AutoDock Vina software by setting the grid parameter as X=-33.163, Y=-65.074 and Z= 41.434 with dimensions of the grid box 25 × 25 × 25 Å. Remdesivir was taken as the standard for comparative analysis along with inhibitor 5, 6, 7-trihydroxy-2-phenyl-4H-chromen-4-one. Furthermore, the exploration of 2 D Hydrogen-bond interactions was performed by Biovia Discovery Studio 4.5 program to identify the interactions between an amino acid of target and ligand followed by assessment of physicochemical properties using Lipinski's rule and Swiss ADME database. The decent bonding scores of secondary metabolites owing to hydrogen bonding with catalytic residues suggest the effectiveness of these phytochemicals towards 3CLpro. The results are further consolidated positively by Lipinski's rule and Swiss ADME prediction. Thus reasonably, observations with docking studies suggest possibility of phytochemicals from Neolamarckia cadamba to inhibit the 3CLpro and consequently would be explored further as agents for preventing COVID-19. © 2023, Universidade Federal de Mato Grosso do Sul, Departamento de Quimica. All rights reserved.
ABSTRACT
Effective career management is essential for all musicians to succeed in the music industry. Understanding, developing and maintaining effective career management is a vital feature for musicians globally. However, in South Africa, this is not the case. There is a concern about musicians who live and die bankrupt for various reasons, including the lack of knowledge about career management. Many South African musicians are famous and rich at the height of their careers, but experience vicious poverty and struggle to support their families after their careers peak. This study aims to discuss and raise awareness about the importance of career management for South African musicians from a talent-preneur skills perspective. A qualitative content analysis was employed to guide this study, grounded in analysing existing scholarly writings such as studies, book chapters, and theses. A narrative thematic analysis was adopted to develop themes from the findings. The following themes were developed to present the findings of this study: 1. Newspaper reported cases of South African musicians;2. Talentpreneurial skills;3. Impact of COVID-19 pandemic on South African musicians;4. Effects of piracy in South African music industry. The results of this study demonstrate that poverty has become a common plight and trend that disturbs South African musicians, and this is partly attributable to the lack of career management. This study affirmed that talent-preneurial skills are essential for musicians to effectively manage their careers. © 2022 Adonis and Abbey Publishers Ltd. All right reserved.